The Temporal Control of Cell Differentiation Laboratory



Building 8, Laboratory 1.14

Department of Biomedical Sciences and Medicine.

University of Algarve

Phone: +351 289244481/90 (lab)

Team Members

Raquel P. Andrade  (Principal Investigator)

Gil Carraço (PhD Student)

Inês Rodrigues (PhD)

Ana Marreiros (PhD)

Patrícia Gomes (PhD Student)

Ana Cristina Fernandes (MsC Student)

Rita Bastos (MsC Student)

Isabel Duarte (Fellowship)

About the TCCD

The developing embryo is a paradigmatic model to study molecular mechanisms of temporal control, since embryonic structures need to differentiate at the right time and place. Our group studies the Embryo Clock (EC) – a molecular oscillator that underlies timely formation of axial skeleton precursors; namely, how the EC pace is set in different tissues and its role in cell fate specification.

Selected Publications

Ramiro Magno, Isabel Duarte, RAQUEL P. ANDRADE, Isabel Palmeirim. 2017 “RDML: A Mathematica package for parsing and importing Real-Time qPCR data”. BMC Res Notes. 10: 208.

Pinto F, Pértega-Gomes N, Vizcaíno JR, RAQUEL P. ANDRADE, Cárcano FM Reis RM. 2016. Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer. Oncotarget 7:28891-902.

Caroline J. Sheeba, RAQUEL P. ANDRADE and Isabel Palmeirim. 2016. Mechanisms of vertebrate embryo segmentation: Common themes in trunk and limb development. Semin Cell Dev Biol.  49:125–134.

Filipe Pinto1,2, Nathalia C Campanella3, Lucas F Abrahão-Machado3,4, Cristovam Scapulatempo-Neto3, Antonio T de Oliveira3,5, Maria J Brito6, RAQUEL P. ANDRADE7, Denise P Guimarães3, Rui M Reis1,2,3. 2015. The embryonic Brachyury transcription factor is a novel biomarker of GIST aggressiveness and poor survival. Gastric Cancer 19:651-9.

Analuce Gouveia1,2, Hugo M. Marcelino1,2, Lisa Gonçalves3,4, Isabel Palmeirim3,4 and RAQUEL P. ANDRADE1,2. 2015. Patterning in Time and Space: HoxB Cluster Gene Expression in the Developing Chick Embryo. Cell Cycle 14:135-45.

Gil Carraco1,2,*, Ana N. Gonçalves1,2,*, Carlos Serra1,2 and RAQUEL P. ANDRADE1,2,3. 2014. MicroRNA processing machinery in the developing chick embryo. Gene Expr Patterns 16:114–121.

Filipe Pinto1,2, Nelma Pértega-Gomes1,2, Márcia S Pereira1,2, José R Vizcaíno3, Pedro Monteiro4, Rui M Henrique5,6,7, Fátima Baltazar1,2, RAQUEL P. ANDRADE1,2, Rui M Reis1,2,8. 2014. T-box transcription factor Brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res 20: 1–13. (Dedicated comment in Nat Rev Urol. 2014. 11:485)

Caroline J. Sheeba1,2, Isabel Palmeirim2* and RAQUEL P. ANDRADE1*. 2014. Limb patterning: from signalling gradients to molecular oscillations. J Mol Biol 426:780-4.*These authors contributed equally to this work. (Featured article; cover caption article)

Caroline J. Sheeba1,2, Isabel Palmeirim2* and RAQUEL P. ANDRADE1*. 2012. Joint Interpretation of AER/FGF and ZPA/SHH Signaling Underlies Dynamic hairy2 Expression in the Chick Limb. Biology Open 1:1102-1110. *These authors contributed equally to this work.

Tatiana P. Resende1, Mónica Ferreira1, Ana Teresa Tavares2,3, Marie-Aimée Teillet4,5, Isabel Palmeirim6* and RAQUEL P. ANDRADE1*. 2010. Sonic hedgehog in temporal control of somite formation. Proc Natl Acad Sci U S A. 107:12907-12. *These authors contributed equally to this work.


Project Grants

As Principal Investigator (PI):

PTDC/BEX-BID/5410/2014 (FCT, Portugal) “TIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification”. 2016-2019.

PTDC/SAU-BID/121459/2010 (FCT/COMPETE, Portugal) “Regulating the pace of the Embryonic Clock: a step forward towards temporal control of cell differentiation”. 2012-2015.

PTDC/SAU-OBD/105111/2008 (FCT/COMPETE, Portugal) “The role of molecular clock genes in temporal control of mesoderm patterning in vertebrate embryos”. 2010-2013.

As Team member:

PTDC/SAU-OBD/099758/2008 (FCT, Portugal) “Molecular parallelisms in vertebrate somitogenesis and limb development”. 2010-2013.

European Network of Excellence “Cells Into Organs: Functional Genomics For Development And Disease Of Mesodermal Organ Systems” (LSH-2002-2.1.4-2). EU/FP6. 2004-2009.

POCI/BIA-BCM/62688/2004 (FCT/POCTI, Portugal) “Identification of molecular interactions in the chick segmentation clock using the Yeast One-hybrid and Two-hybrid approaches”. 2005-2008.

Representative Images

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