The Drosophila Development Laboratory

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Location

Building 8, Laboratory 1.16

Department of Biomedical Sciences and Medicine.

University of Algarve

Phone: +351 289 800 094

rgmartinho@ualg.pt

Team Members

Rui Martinho (Principal Investigator)

Paulo Costa (Post Doctoral Researcher)

Ana Luísa Ribeiro (Post Doctoral Researcher)

Rui Silva (Post Doctoral Researcher)

Pedro Prudêncio (PhD Student)

Om Singh Rathore (PhD Student)

Margarida Neto (Laboratory Manager)

Ricardo Matos (MsC Student)

About the DDL

Normal development and maintenance of adult organism homeostasis relies on a regulatory cross talk between tissue morphogenesis, differentiation and cell division, which is crucial for organogenesis and for tissue integrity, growth and renewal. Our main research interest is to take advantage of Drosophila melanogaster as a model system to study tissue morphogenesis and cell division during development. Since tumorigenesis is frequently associated with loss of tissue integrity and misregulation of cell proliferation, we expect this work will give a contribution into a better understanding of molecular and cellular processes associated with the onset and development of cancer. More information can be found here and here.

Publications (2008-2014)

Martinho R.G., Castel S., Urena J., Fernandez-Borja M., Makiya R., Olivecrona G., Reina M., Alonso A. and Vilaro S. (1996). Ligand binding to Heparan Sulfate Proteoglycans Induces Their Aggregation and Distribution along Actin Cytoskeleton. Mol Biol Cell, Nov; 7 (11): 1771-1788. (Times cited: 39*)

(JCR 1997 impact factor of MOLECULAR BIOLOGY OF THE CELL is 8.926)
(Top 5% journal – category “Molecular Biology” according to SJR year 1999)

*Number of citations according to Google Scholar (6th May 2015).

Martinho R.G., Lindsay H.D., Flaggs G., DeMaggio A.J., Hoekstra M.F., Carr A.M., and Bentley N.J. (1998). Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. EMBO J., Dec 15; 17 (24): 7239-7249. (Times cited: 158*)

(JCR 1998 impact factor of EMBO JOURNAL is 13.171)
(Top 5% journal – category “Biochemistry, Genetics and Molecular Biology” according to SJR year 1999)

Christensen P.U., Bentley N.J., Martinho R.G., Nielsen O, and Carr A.M. (2000). Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis. Proc. Natl. Acad. Sci. U S A, Mar 14; 97 (6): 2579-2584. (Times cited: 62*)

(JCR 2000 impact factor of PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA is 10.79)
(Top 5% journal – category “Multidisciplinary” according to SJR year 2000)

Read R.L., Martinho R.G., Wang S.W., Carr A.M., and Norbury C.J. (2002). Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc. Natl. Acad. Sci. U S A, Sep 17; 99 (19): 12079-12084. (Times cited: 94*)

(JCR 2002 impact factor of PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA is 10.70)
(Top 5% journal – category “Multidisciplinary” according to SJR year 2002)

Martinho R.G., Kunwar P.S., Casanova J., and Lehmann R. (2004). A non-coding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells. Current Biology, 14 (2): 159-165. (Times cited: 95*)

(JCR 2004 impact factor of CURRENT BIOLOGY is 11.90)
(Top 5% journal – category “Biochemistry, Genetics and Molecular Biology (miscellaneous)” according to SJR year 2004)

(This publication was featured in “Science Editor’s Choice” for highlights in recent literature, Science, vol. 303, Feb 6, 2004; and “Research Notes”, Nature Structural and Molecular Biology, vol. 11, Mar 2004).

Pimenta-Marques, A., Tostões, R., Marty, T., Barbosa, V., Lehmann, R., and Martinho R.G. (*) (2008). Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. Developmental Biology, Nov 15; 323 (2): 197-206. (*) corresponding author. (Times cited: 26*)

(JCR 2008 impact factor of DEVELOPMENTAL BIOLOGY is 4.416)
(Journal of Quartile 1 – category “Developmental Biology” according to SJR year 2008)

Rangan P., DeGennaro M., Jaime-Bustamante K. , Coux R., Martinho R.G., and Lehmann R. (2009). Temporal and spatial control of germ plasm RNAs. Current Biology, 19(1):72-7. (Times cited: 38*)

(JCR 2009 impact factor of CURRENT BIOLOGY is 10.992)
(Top 5% journal – category “Biochemistry, Genetics and Molecular Biology (miscellaneous)” according to SJR year 2009)

de las Heras J.M. (*), Martinho R.G. (*), Lehmann R, and Casanova J. (2009). A functional antagonism between pgc and torso in the development of the germ-line and somatic cells. EMBO Reports, Sep;10(9):1059-65. (*) authors gave an equal contribution. (Times cited: 5*)

(JCR 2009 impact factor of EMBO REPORTS is 6.907)
(Journal of Quartile 1 – category “Genetics” according to SJR year 2009)

Van Damme, P. (*), Hole, K. (*), Pimenta-Marques, A. (*), Helsens, K., Vandekerckhove, J., Martinho, R.G., Gevaert, K., Arnesen, T. (2011). NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation PLoS GENETICS, Jul; 7 (7): e1002169. (Times cited: 3*). (*) Authors gave an equal contribution.

(Times cited: 53*)

(JCR 2011 impact factor of PLOS GENETICS is 8.694)
(Top 5% journal – category “Molecular Biology” according to SJR year 2011)

Guilgur L., Prudêncio P., Ferreira T., Pimenta-Marques A., Martinho, R.G. (*) (2012). Drosophila aPKC is required for mitotic spindle orientation in larval wing discs. DEVELOPMENT, Feb;139(3):503-13. (*) Corresponding author. (Times cited: 24*)

(JCR 2012 impact factor of DEVELOPMENT is 6.208)
(Journal of Quartile 1 – category “Developmental Biology” according to SJR year 2012)

Alves E., Henriques B.J., Rodrigues J.V., Prudêncio P., Rocha H., Vilarinho L., Martinho R.G. (*), Gomes C.M. (*) (2012). Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila. Biochim Biophys Acta – Molecular Basis of Disease, May 9; 1822 (8): 1284-1292. (*) Co-corresponding authors. (Times cited: 2*)

(JCR 2012 impact factor of BBA-Molecular Basis of Disease is 4.91)
(Journal of Quartile 1 – category “Molecular Biology” according to SJR year 2012)

(This publication was featured on the cover of BBA-Molecular Basis of Disease)

Guilgur L., Prudêncio P., Sobral D., Lisekova D., Martinho R.G.(*). (2014). Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. eLife. 2014 Apr 22;3:e02181. doi: 10.7554/eLife.02181.(*) Corresponding author. (Times cited: 6*)

(JCR 2014 impact factor of eLife is 9.322)
(Top 5% journal – category “Medicine (miscellaneous)” according to SJR year 2013)

Pereira P.A., Navarro-Costa P., Martinho R.G. and Becker J.D. (2014). Evolutionarily conserved mechanisms of male germline development in flowering plants and animals. Biochemical Society Transactions. Apr;42(2):377-82. doi: 10.1042/BST20130261. (Times cited: 1*)

(JCR 2014 impact factor of Biochemical Society Transactions is 3.194)
(Journal of Quartile 1 – category “Biochemistry” according to SJR year 2013)

Ferreira T, Prudêncio P, Martinho R.G. (*) (2014). Drosophila protein kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis. Developmental Biology. 2014 Oct 15;394(2):277-91. (*) Corresponding author. Times cited: 1*)

(JCR 2014 impact factor of Developmental Biology is 3.547)
(Journal of Quartile 1 – category “Developmental Biology” according to SJR year 2013)

(This publication was featured on the cover of Developmental Biology)

Martinho R.G. (*) , Guilgur L.G., Prudêncio P. (2015). How gene expression in fast-proliferating cells keeps pace. Bioessays. 2015 May;37(5):514-24. (*) corresponding author.

(JCR 2014 impact factor of BioEssays is 4.730)
(Journal of Quartile 1 – category “Biochemistry, Genetics and Molecular Biology (miscellaneous)” according to SJR year 2013)

Silva R. and Martinho R.G. (*) (2015). Developmental roles of Protein N-terminal acetylation. Proteomics. 2015 Jul;15(14):2402-9. (*) corresponding author. (Times cited: 1*)

(JCR 2014 impact factor of Proteomics is 3.807)
(Journal of Quartile 1 – category “Biochemistry” according to SJR year 2013)

Project Grants

PTDC/BIA-BCM/111822/2009 – Constraints on gene expression during early embryonic development. (2011- 2014)

PTDC/QUI-BIQ/113027/2009 – Analysis of the role of N-terminal acetyltransferases during Drosophila development. (2011- 2014)

PTDC/SAU-BID/111796/2009 – Characterization of mesenchymal to epithelial transition in Drosophila melanogaster. (2011- 2014)

Patents

Provisional application with the US Patent Office: Thelial Patent – 7526/83099-PRO

Team

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