The Drosophila Development Laboratory



Building 8, Laboratory 1.16

Department of Biomedical Sciences and Medicine.

University of Algarve

Phone: +351 289 800 094

Team Members

Rui Martinho (Principal Investigator)

Paulo Costa (Post Doctoral Researcher)

Rui Silva (Post Doctoral Researcher)

Bruno Marques (PhD Student)

Pedro Prudêncio (PhD Student)

Om Singh Rathore (PhD Student)

Margarida Neto (Laboratory Manager)

Ricardo Matos (MsC Student)

About the DDL

Normal development and maintenance of adult organism homeostasis relies on a regulatory cross talk between tissue morphogenesis, differentiation and cell division, which is crucial for organogenesis and for tissue integrity, growth and renewal. Our main research interest is to take advantage of Drosophila melanogaster as a model system to study tissue morphogenesis and cell division during development. Since tumorigenesis is frequently associated with loss of tissue integrity and misregulation of cell proliferation, we expect this work will give a contribution into a better understanding of molecular and cellular processes associated with the onset and development of cancer. More information can be found here and here.

Publications (2008-2017)

1) Paulo Navarro-Costa, Alicia McCarthy, Pedro Prudêncio, Gastón Guilgur, Jörg D. Becker, Prashanth Rangan (*) and Rui Gonçalo Martinho (*) (2016). Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin architecture. NATURE COMMUNICATIONS, Aug 10; 7: 12331. doi: 10.1038/ncomms12331 (Times cited: 2+/ 2++/ 1+(*) Co-Corresponding authors. (2016/2017 Journal impact factor of Nature Communications is 12.124).

2) Ana L. Ribeiro, Rui D. Silva, Håvard Foyn, Margarida N. Tiago, Pedro Prudêncio, Om S. Rathore, Thomas Arnesen, Rui Gonçalo Martinho (*) (2016). Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion. SCIENTIFIC REPORTS, Dec 20; 6: 39118. doi: 10.1038/srep39118. (*) Corresponding author.(2016/2017 Journal impact factor of Scientific Reports is 4.259)

3) Om Singh Rathore, Alexandra Faustino, Pedro Prudêncio, Petra Van Damme, Cymon J. Cox, Rui Gonçalo Martinho (*) (2016). Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. SCIENTIFIC REPORTS, Feb 10; 6: 21304. doi: 10.1038/srep21304 (Times cited: 6+/ 6++/ 5+++(*) Corresponding author. (2016/2017 Journal impact factor of Scientific Reports is 4.259).

4) Silva R. and Martinho R.G. (*). (2015). Developmental roles of Protein N-terminal acetylation. PROTEOMICS, 15 (14), 2402-2409. doi: 10.1002/pmic.201400631 (Times cited: 14+/ 8++/ 7+++(*) Corresponding author. (2015 Journal impact factor of Proteomics is 4.079).

5) Martinho R.G. (*), Guilgur L., Prudêncio P. (2015). How gene expression in fast-proliferating cells keeps pace. BIOESSAYS, May; 37 (5): 514-24. doi: 10.1002/bies.201400195 (Times cited: 3+/ 2++/ 2++(*) Corresponding author. (2015 Journal impact factor of Bioessays is 4.725).

6) Guilgur L., Prudêncio P., Sobral D., Lisekova D., Rosa A., Martinho R.G. (*). (2014). Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. ELIFE, Apr22; 3: e02181. doi: 10.7554/eLife.02181 (Times cited: 18+/ 15++/ 15+++). (*) Corresponding author. (2014  Journal impact factor of eLife is 9.322).

7) Ferreira T., Prudêncio P., Martinho R.G. (*) (2014). Drosophila Protein Kinase N (Pkn) is a negative regulator of actin-myosin activity during oogenesis. DEVELOPMENTAL BIOLOGY, Oct 15; 394 (2): 277-91. doi: 10.1016/j.ydbio.2014.08.008 (Times cited: 4+/ 3++/ 2+++(*) Corresponding author. (This publication was featured on the cover of Developmental Biology) (2014 Journal impact factor of Developmental Biology is 3.547).

8) Pereira P.A., Navarro-Costa P., Martinho R.G. and Becker J.D. (2014). Evolutionarily conserved mechanisms of male germline development in flowering plants and animals. BIOCHEMICAL SOCIETY TRANSACTIONS, 42 (2): 377-82. doi: 10.1042/BST20130261 (Times cited: 3+/ 3++/ 2+++) (2014 Journal impact factor of Biochemical Society Transactions is 3.194).

9) Alves, E., Barbara, H., Rodrigues, J. V., Prudêncio, P., Rocha, H., Vilarinho, L., Martinho, R.G. (*), Gomes, C.M. (*) (2012). Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, vol. 1822 (8): 1284-1292. doi: 10.1016/j.bbadis.2012.05.003 (Times cited: 3+/ 1++/ 1+++(*) Co-corresponding authors. (2012 Journal impact factor of BBA-Molecular Basis of Disease is 4.91)(This publication was featured on the cover of BBA-Molecular Basis of Disease).

10) Guilgur L., Prudêncio P., Ferreira T., Pimenta-Marques A., Martinho R.G. (*) (2012). Drosophila aPKC is required for mitotic spindle orientation in larval wing discs. DEVELOPMENT, Feb; 139 (3): 503-13. doi: 10.1242/dev.071027 (Times cited: 37+/ 30++/ 28+++(*) Corresponding author. (2012 Journal impact factor of DEVELOPMENT is 6.208).

11) Petra Van Damme (*), Kristine Hole (*), Ana Pimenta-Marques (*), Kenny Helsens, Joël Vandekerckhove, Rui G. Martinho, Kris Gevaert, Thomas Arnesen. (2011). NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation PLOS GENETICS, Jul; 7 (7): e1002169. doi: 10.1371/journal.pgen.1002169 (Times cited: 96+/ 68++/ 58+++) (*) Authors gave an equal contribution. (2011 Journal impact factor of PLOS GENETICS is 8.694).

12) de las Heras J.M. (*), Martinho R.G. (*), Lehmann R, and Casanova J. (2009). A functional antagonism between pgc and torso in the development of the germ-line and somatic cells. EMBO REPORTS, Sep; 10 (9): 1059-65. doi: 10.1038/embor.2009.128 (Times cited: 9+/ 5++/ 3+++)
(*) Authors gave an equal contribution. (2009 Journal impact factor of EMBO REPORTS is 6.907)

13) Rangan P., DeGennaro M., Jaime-Bustamante K. , Coux R., Martinho R.G., and Lehmann R. (2009). Temporal and spatial control of germ plasm RNAs. CURRENT BIOLOGY, 19(1):72-7. doi: 10.1016/j.cub.2008.11.066 (Times cited: 57+/ 43++/ 36+++)(2009 Journal impact factor of CURRENT BIOLOGY is 10.992).

14) Pimenta-Marques A., Tostões R., Marty T., Barbosa V., Lehmann R., Martinho R.G. (*) (2008). Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. DEVELOPMENTAL BIOLOGY, 323 (2): 197-206. doi: 10.1016/j.ydbio.2008.08.021 (Times cited: 35+/ 26++/ 27+++). (*) Corresponding author (2008 Journal impact factor of DEVELOPMENTAL BIOLOGY is 4.416).

15) Martinho R.G., Kunwar P.S., Casanova J., and Lehmann R. (2004). A non-coding RNA is required for the repression of RNApolII-dependent transcription in primordial germ cells. CURRENT BIOLOGY, 14 (2): 159-165. doi: 10.1016/j.cub.2003.12.036 (Times cited: 116+/ 90++/ 92+++(Feature in “Science Editor’s Choice” for highlights in recent literature; Science, vol. 303, Feb 6, 2004, and “Research Notes”; Nature Structural and Molecular Biology, vol. 11, Mar 2004.) (2004 Journal impact factor of CURRENT BIOLOGY is 11.90).

16) Read R.L., Martinho R.G., Wang S.W., Carr A.M., and Norbury C.J. (2002). Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, 2002 Sep 17; 99 (19): 12079-12084. doi: 10.1073/pnas.192467799 (Times cited: 99+/ 77++/ 76+++) . (2002 Journal impact factor of PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA is 10.70)

17) Christensen P.U., Bentley N.J., Martinho R.G., Nielsen O, and Carr A.M. (2000). Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, Mar 14; 97 (6): 2579-2584. doi: 10.1073/pnas.97.6.2579 (Times cited: 68+/ 53++/ 53+++). (2000 Journal impact factor of PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA is 10.79).

18) Martinho R.G. and Carr A.M. (1999). Isolation of DNA structure-dependent Checkpoint Mutants in S. pombe. “DNA repair protocols”-Methods in Molecular Biology. Humana Press Inc. doi: 10.1385/1-59259-675-4:1 (Times cited: 2+).

19) Martinho R.G., Lindsay H.D., Flaggs G., DeMaggio A.J., Hoekstra M.F., Carr A.M., and Bentley N.J. (1998). Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. EMBO JOURNAL, Dec 15; 17 (24): 7239-7249. doi: 10.1093/emboj/17.24.7239 (Times cited: 167+/ 128++/ 130+++). (1998 Journal impact factor of EMBO JOURNAL is 13.171).

20) Martinho R.G., Castel S., Urena J., Fernandez-Borja M., Makiya R., Olivecrona G., Reina M., Alonso A. and Vilaro S. (1996). Ligand binding to Heparan Sulfate Proteoglycans Induces Their Aggregation and Distribution along Actin Cytoskeleton. MOLECULAR BIOLOGY OF THE CELL, Nov; 7 (11): 1771-1788. doi: 10.1091/mbc.7.11.1771 (Times cited: 42+/ 32++/ 33+++). (1997 Journal impact factor of MOLECULAR BIOLOGY OF THE CELL is 8.926).

+ Número de citações de acordo com o “Google Scholar” (19 de Setembro 2017)

Método utilizado busca no Google Scholar: “Rui Gonçalo Martinho”

++ Número de citações de acordo com “Scopus” (19 Setembro 2017)

Método utilizado busca no Scopus: “Rui Gonçalo” e  “Martinho” (First and Last name)

+++ Número de citações de acordo com “Web of Science” (19 Setembro 2017)

Método utilizado busca no ISI Web of Science: “martinho rg” (Author)

Project Grants

FCT I&D Project: PTDC/SAU-BID/111796/2009 (2011-2014). Principal Investigator: Rui Gonçalo Martinho. Title: “Estudo da transição mesênquima-epitélio em Drosophila melanogaster“. Funding: 120.000 euros.

FCT I&D Project: PTDC/BBB-BQB/0712/2012 (2013-2015). Principal Investigator: Rui Gonçalo Martinho. Title: “Segregação de proteínas e acetilação N-terminal”. Funding: 194.664 euros.

FCT I&D Project: PTDC/BEX-BID/0395/2014 (2016-2019). (Ongoing Project). Principal Investigator: Rui Gonçalo Martinho. Title: “Obstáculos moleculares ao processamento de pre-mRNAs durante uma rápida proliferação celular”. Funding: 198.831 euros.


1) USPTO Patent: US9416391 B2

Rui Gonçalo Martinho, Virginia Oliveira Marques, and Richard John Hampson (2016). Method for identifying cancer drug candidates in Drosophila. US9416391 B2

(patente Norte-Americana concedida em 16 de Agosto de 2016)



Representative Images

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