i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto
Nuno Rodrigues dos Santos (Principal Investigator)
Ivette Pacheco-Leyva (Postdoctoral Fellow)
Marta Araújo (Master Student)
Marina Baessa (Master Student)
About the MBLL
The Molecular Biology of Leukaemia laboratory (MBLL) investigates the molecular and cellular mechanisms underlying leukaemia development using a range of biological models. Special interest is devoted to the research of mechanisms involved in molecular crosstalk with the micro-environment surrounding the cancer cells and the role of cell surface proteins (eg lymphotoxin and chemokine receptors) in leukaemogenesis. The MBLL group is actively investigating proteins and signalling pathways that are expressed and/or activated in leukaemia cells and leukaemia-associated stromal cells that contribute to leukaemogenesis. The long-term goal of the MBLL is to divulge how lymphocytes are malignantly transformed and pave the way for the development of new therapeutic approaches to treat lymphoma and leukaemia.
Trinquand A*, DOS SANTOS NR*, Tran Quang C*, Rocchetti F, Zaniboni B, Belhocine M, de Jesus CC, Lhermitte L, Tesio M, Dussiot M, Cosset F-L, Verhoeyen E, Pflumio F, Ifrah N, Dombret H, Spicuglia S, Chatenoud L, Gross D-A, Hermine O, Macintyre E, GhysdaeL J, Asnafi V. (2016) Triggering the TCR developmental checkpoint activates a therapeutically targetable tumor suppressive pathway in T-cell leukemia. Cancer Discovery, 6:972-985. DOI: 10.1158/2159-8290.CD-15-0675. *, first co-authorship
Fernandes MT, Dejardin E, dos Santos NR. (2016) Context-dependent roles for lymphotoxin-β receptor signaling in cancer development. Biochim Biophys Acta – Reviews on Cancer, 1865:204-219. DOI: 10.1016/j.bbcan.2016.02.005
Fernandes MT, Ghezzo MN, Silveira AB, Kalathur RK, Póvoa V, Ribeiro AR, Brandalise SR, Dejardin E, Alves NL, Ghysdael J, Barata JT, Yunes JA, dos Santos NR. (2015) Lymphotoxin-β receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype. British Journal of Haematology, 171:736-751. DOI: 10.1111/bjh.13760.
Mouffouk F, Simão T, Dornelles D, Lopes AD, Sau P, Martins J, Abu-Salah KM, Alrokayan SA, Rosa da Costa AM, dos Santos NR. (2015) Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging. International Journal of Nanomedicine, 10:63-76. DOI: 10.2147/IJN.S71190.
Zanella F, dos Santos NR, Link W. (2013) Moving to the core: spatiotemporal analysis of Forkhead box O (FOXO) and Nuclear factor-κB (NF-κB) nuclear translocation. Traffic, 14:247-258.
dos Santos NR, Ghezzo MN, Silva RC, Fernandes MT. (2010) NF-κB in T-cell acute lymphoblastic leukemia: oncogenic functions in leukemic and in microenvironmental cells. Cancers, 2:1838-1860.
dos Santos NR, Williame M, Gachet S, Cormier F, Janin A, Weih D, Weih F, Ghysdael J. (2008). RelB-dependent stromal cells promote T-cell leukemogenesis.PLoS ONE, 3(7):e2555.
Project Leader (PI)
PTDC/SAU-OBD/103336/2008 – “Influence of Thymic Stromal cells and chemokine signaling in acute T-cell leukaemia development”.
Núcleo Regional Sul da Liga Portuguesa Contra o Cancro – Terry Fox “RelB expression in the thymus and acute T-cell leukemia development”, 2009-2011.
“Memorandum of Understanding Between King Saud University and University of Algarve on Research and Development in Nanotechnology and Other Disciplines”, King Abdulla Institute for Nanotechnology, King Saud University, Riyadh, Kingdom of Saudi Arabia.