The Cell Cycle and Cancer Biology Laboratory

alvarotavares
claudiaflorindo

Location

Building 8, Laboratory 1.17

Department of Biomedical Sciences and Medicine.

University of Algarve

Phone: +351 289 244 480

aatavares@ualg.pt

cstavares@ualg.pt

Team Members

Álvaro Tavares  (Principal Investigator)

Claudia Florindo (Independent researcher)

Ricardo Jerónimo Assanhas Sutil Resende (MSc in OncoBiology)

Seyar Ablyazizov (MSc in OncoBiology)

Tânia Isabel Carvão Carriço (MSc in OncoBiology: co-supervision of Maria João Bebiano)

Elna Iliana Lima Fernandes (MSc in OncoBiology: co-supervision of Maria João Bebiano)

About the CCBL

The Cell Cycle and Cancer Biology Laboratory (CCBL) investigates the mechanisms by which the deregulation of cell division can lead to tumor formation. The CCBL is focused on two crucial processes during mitosis: i) chromosome attachment to the spindle and ii) the completion of cell division (cytokinesis). Using a broad range of classic genetic and cellular models, the CCBL group has identified a set of new genes that significantly affect chromosome segregation, spindle assembly and abscission. When mutated, some of these genes cause the formation of tumors in Drosophila, indicating that the human homologues may equally be involved in tumorigenesis.

More information: http://alvarotavare.wixsite.com/mitosisgroup

Publications (2008-2017)

Machado VM, Lourenço AS, Florindo C, Fernandes R, Carvalho CM, Araújo IM (2017) Overexpression of calpastatin preserves cognitive function following seizures, while mantaining post-injury neurogenesis. Frontiers in Molecular Neuroscience 10:60.

Patrícia M.A. Silva, Maria Leonor Delgado, Nilza Ribeiro, Cláudia Florindo, Álvaro A. Tavares, Hassan Bousbaa, and Luís Silva Monteiro “ Spindly Expression, Prognostic Significance and Therapeutic Implications in Oral Squamous Cell Carcinoma”, 2017, submitted Oncogene.

Patrícia M.A. Silva, Nilza Ribeiro, Raquel Lima, Cláudia Andrade, Vânia Diogo, Joana Teixeira, Cláudia Florindo, Álvaro A. Tavares, Helena Vasconcelos and Hassan Bousbaa. “Suppression of Spindly Delays Mitotic Exit and Exacerbates Cell Death Response of Cancer Cells Treated with Low Doses of Paclitaxel.”  Cancer Letters. 2017;394:33-42.

Florindo, C, Ferreira, B., Serrão, S., Tavares, AA, and Link, W. (2016) “Subcellular Protein Localisation in Health and Disease” – eLS 2016 (Encyclopedia of Life Sciences).

“International Manual of Oncology Practice. (iMOP) – Principles of Medical Oncology.”  de Mello RA, Tavares ÁA, Mountzios G (Eds.). Springer International Publishing. 2015. eBook ISBN: 978-3-319-21683-6. Hardcover ISBN 978-3-319-21682-9

Silva PM, Tavares ÁA, Bousbaa H. (2015) “Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments.” FEBS Lett. 589:3588-94.

Silva PM, Reis RM, Bolanos-Garcia VM, Florindo C, Tavares ÁA, Bousbaa H. (2014) Dynein-dependent transport of spindle assembly checkpoint proteins off kinetochores toward spindle poles. FEBS Lett. 588:3265-3273.

Marco A. Campinho, João Saraiva, Claudia Florindo, Deborah M. Power. (2014) “Maternal thyroid hormones are essential for neural development in zebrafish”. Molecular Endocrinology 28:1136-1149

Rafael MS, Laizé V, Florindo C, Ferraresso S, Bargelloni L, Cancela ML. Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts. Biochimie. 2012 May;94(5):1128-34. doi: 10.1016/j.biochi.2012.01.013. Epub 2012 Jan 20.

Pereira H, Barreira L, Mozes A, Florindo C, Polo C, Duarte CV, Custódio L, Varela J. Microplate-based high throughput screening procedure for the isolation of lipid-rich marine microalgae. Biotechnol Biofuels. 2011 Dec 22;4(1):61. doi: 10.1186/1754-6834-4-61. PMID:22192119

Florindo C, Perdigão, J., Fesquet, D., Schiebel, E., Pines, J. and Tavares A.A. (2012) “ Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.” J. Cell Sci 125: 3085-3090.

Tavares A., Gonçalves J., Florindo C, Tavares A.A. and Soares H. (2012) Mob1: defining cell polarity for proper cell division. J. Cell Sci 125:516-527.

Lince-Faria, M., Maffini, S., Orr, B., Ding, Y., Florindo, C., Sunkel, C.E., Tavares, A.A., Johansen, J., Johansen, K. M. and Maiato, H. (2009) “Spatio-temporal control of mitosis by the conserved spindle matrix protein Megator” J. Cell Biology 184:647-657.

Godinho, S. and Tavares, A.A. (2008) “A role for Drosophila Polo protein in chromosome resolution and segregation during mitosis”, Cell Cycle 7:2529 – 2534.

Projects

EXPL/BEX-BCM/1140/2013 – “Mechanisms of cell polarity in cytokinesis: a Chromophore-Assisted Laser Inactivation approach”, Principal Investigator Cláudia Florindo

Project Leader

PTDC/SAU-OBD/105234/2008- Role of Mob1 and Unc119 proteins in cytokinesis and tumorogenesis. (2010 – 2012)

Colaborator

PTDC/BIA-BCM/69912/2006 (2008 – 2010)

PTDC/SAU-NEU/81153/2006 (2008 – 2010)

Team

alvarotavares_team

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