Sónia Simão, CBMR researcher, published recently 4 articles focused on the study of the cellular mechanisms underlying the pathogenesis of diabetic retinopathy. Using in vitro and in vivo models, that mimic the diabetic retinopathy, Sonia Simão and her team try to clarify what intracellular pathways are really changed.
Article 1 – Angiogenesis
Aliskiren decreases oxidative stress and angiogenic markers in retinal pigment epithelium cells.
Article 2 – European Journal of Pharmaceutical Sciences
Aliskiren inhibits the renin-angiotensin system in retinal pigment epithelium cells.
Article 3 – Molecular Vision
GLUT1 activity contributes to the impairment of PEDF secretion by the RPE.
Article 4 – New Frontiers in Ophthalmology
Oxidative stress modulates the expression of VEGF isoforms in the diabetic retina