Clévio Nóbrega, CBMR researcher, published recently on the British Medical Bulletin the article: “The contribution of genetics and environment to obesity”.
Know more about the article here.
Abstract: Obesity is a global health problem mainly attributed to lifestyle changes such as diet, low physical activity or socioeconomics factors. However, several evidences consistently showed that genetics contributes significantly to the weight-gain susceptibility.
Areas of controversy: After more than 10 years of investigation on the genetics of obesity, the variants found associated with obesity represent only 3% of the estimated BMI-heritability, which is around 47–80%. Moreover, genetic factors per sewere unable to explain the rapid spread of obesity prevalence.
Growing points: The integration of multi-omics data enables scientists having a better picture and to elucidate unknown pathways contributing to obesity.
Areas timely for developing research: New studies based on case–control or gene candidate approach will be important to identify new variants associated with obesity susceptibility and consequently unveiling its genetic architecture. This will lead to an improvement of our understanding about underlying mechanisms involved in development and origin of the actual obesity epidemic. The integration of several omics will also provide insights about the interplay between genes and environments contributing to the obese phenotype.