Clévio Nóbrega, CBMR researcher and DCBM teacher, published, in the last months, three review articles associated with polyglutamine diseases:
- Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review – a review about all transgenic models that are used for the study of spinocerebellar ataxia type 2 (SCA2).
- Proteolytic cleavage of polyglutamine disease-causing proteins: revisiting the toxic fragment hypothesis – a review about a pathological mechanism involved in the different polyglutamine ataxias.
- Unraveling the Role of Ataxin-2 in Metabolism – a review that provides, for the first time, clues to understand the role of ataxin-2 (which causes SCA2).
Know more about the research of Clévio Nóbrega here.