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CBMR students obtained doctoral and post-doctoral FCT research grants

Adriana Marcelo and Catarina Paulino obtained doctoral and post-doctoral FCT research grants for the development of their investigations over the next years. To the referred students CBMR wishes congratulations and all the success for the future!

Adriana Marcelo – Doctoral Research Grant FCT 2017 – Project “Stress granules as new players in Polyglutamine diseases: from pathogenesis to therapeutic strategies”

Catarina Paulino – Post-Doctoral Research Grant FCT 2016- “Anger vs. happiness: which comes first? The time course of emotional word recognition” (Supervisors: Alexandra Reis e Luís Faísca)

 

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Clévio Nóbrega publishes on British Medical Bulletin

Clévio Nóbrega, CBMR researcher, published recently on the British Medical Bulletin the article: “The contribution of genetics and environment to obesity”.

Know more about the article here.

Abstract: Obesity is a global health problem mainly attributed to lifestyle changes such as diet, low physical activity or socioeconomics factors. However, several evidences consistently showed that genetics contributes significantly to the weight-gain susceptibility.

Areas of controversy: After more than 10 years of investigation on the genetics of obesity, the variants found associated with obesity represent only 3% of the estimated BMI-heritability, which is around 47–80%. Moreover, genetic factors per sewere unable to explain the rapid spread of obesity prevalence.
Growing points: The integration of multi-omics data enables scientists having a better picture and to elucidate unknown pathways contributing to obesity.
Areas timely for developing research: New studies based on case–control or gene candidate approach will be important to identify new variants associated with obesity susceptibility and consequently unveiling its genetic architecture. This will lead to an improvement of our understanding about underlying mechanisms involved in development and origin of the actual obesity epidemic. The integration of several omics will also provide insights about the interplay between genes and environments contributing to the obese phenotype.

 

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Available postdoctoral position at “The Drosophila Development Laboratory”

A postdoctoral position is available at The Drosophila Development Laboratory for analysis of the epigenetic regulation of gene expression during oocyte reactivation and fast cell proliferation in Drosophila melanogaster and human cells. To bypass limitations of “standard” steady-state RNAseq approaches, we are currently optimising nascent RNA transcriptomics approaches for developing embryos.
Applications of highly motivated postdoctoral researchers, willing to learn state-of-the-art transcriptomics approaches, and not afraid of being involved in a international collaborative effort, are strongly encourage to apply. This project will be developed in close collaboration with Maria Carmo-Fonseca laboratory (IMM, Lisbon).
Ideal candidates should have: i) a previous experience with Drosophila melanogaster and/or tissue culture of human cells, qRT-PCR, chromatin purification, and RNAseq techniques; and/or ii) a strong background in computational biology and experience in the analysis of RNAseq datasets.
For more information please send email to: rgmartinho@ualg.pt
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Inês Araújo and Ana Isabel Santos publish on The Antioxid Redox Signal Journal

Inês Araújo and Ana Isabel Santos, CBMR researchers, published recently on the Antioxid Redox Signal Journal the article: “S-nitrosylation of Ras mediates nitric oxide dependent post-injury neurogenesis in a seizure model”.

Know more about the article here.

Abstract: Nitric oxide (NO) is involved in the upregulation of endogenous neurogenesis in the subventricular zone and in the hippocampus after injury. One of the main neurogenic pathways activated by NO is the ERK/MAPK pathway, downstream of the EGF receptor. However, the mechanism by which NO stimulates cell proliferation through activation of the ERK/MAPK pathway remains unknown, although p21Ras seems to be one of the earliest targets of NO. Here, we aimed to study the possible neurogenic action of NO by post-translational modification of p21Ras as a relevant target for early neurogenic events promoted by NO in neural stem cells (NSC).

Results: We show that NO caused S-nitrosylation of p21Ras in Cys118, which triggered downstream activation of the ERK/MAPK pathway and proliferation of NSC. Moreover, in cells overexpressing a mutant Ras in which Cys118 was replaced by a serine -C118S-, cells were insensitive to NO, and no increase in S-nitrosylation, in ERK phosphorylation or in cell proliferation were observed. We also show that, following seizures, in the presence of NO derived from inducible nitric oxide synthase, there was an increase in p21Ras cysteine modification concomitant with the previously described stimulation of proliferation in the dentate gyrus.

Innovation: Our work identifies p21Ras and its S-nitrosylation as an early target of NO during signaling events that lead to NSC proliferation and neurogenesis.

Conclusion: Our data highlight Ras S-nitrosylation as an early event leading to NSC proliferation, and may provide a target for NO-induced stimulation of neurogenesis with implications for brain repair.

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Cryocube Project open 2 Research grants to Master Degree

The Cryocube Project, funded by Fundo Europeu de Desenvolvimento Regional (FEDER), is recruiting 2 Research grants to Master Degree. If you are highly motivated, creative, curious, perseverant, dynamic and share a commited passion for Biological Sciences, Biochemistry, Biotechnology, Pharmacy and Biological Engineering, please apply.

Requirements: Master’s degree in the scientific areas mentioned above.

Fellow 1 – we are looking for someone with experience in expression and purification of recombinant proteins in Escherichia coli and experience in spectroscopic techniques, particularly, fluorescence.

Fellow 2- we are looking for someone with experience in animal cell culture and electrophoretic techniques, particularly western blot.

Workplace: Center for Biomedical Research – CBMR  (UAlg), under the scientific guidance of Professor Eduardo Pinho e Melo.

Duration: 10 months

Amount: 980 euros

Deadline for applications: 20/07/2017

Applications should be sent toemelo@ualg.pt with the following documents:

– Curriculum Vitae;

– Academic Certificate;

– Identity Card / Passport;

– Fiscal Identification Number;

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Wolfgang Link publishes on The International Journal of Cancer

Wolfgang Link, CBMR researcher, published recently on The International Journal of Cancer the article: “FOXO transcription factors at the interface of metabolism and cancer”.

Know more about the article here.

Abstract: Diabetes refers to a group of metabolic diseases characterized by impaired insulin signalling and high blood glucose. A growing body of epidemiological evidence links diabetes to several types of cancer but the underlying molecular mechanisms are poorly understood. The signalling cascade connecting insulin and FOXO proteins provides a compelling example for a conserved pathway at the interface between insulin signalling and cancer. FOXOs are transcription factors that orchestrate programs of gene expression known to control a variety of processes in response to cellular stress. Genes regulated by this family of proteins are involved in the regulation of cellular energy production, oxidative stress resistance and cell viability and proliferation. Accordingly, FOXO factors have been shown to play an important role in the suppression of tumour growth and in the regulation of metabolic homeostasis. There is emerging evidence that deregulation of FOXO factors might account for the association between insulin resistance-related metabolic disorders and cancer.

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CBMR signs protocol of collaboration with University of Leicester

In June, a protocol of collaboration was established between the CBMR (University of Algarve) and the University of Leicester (UoL, United Kingdom). The members of this collaboration are the researchers Karl Magnus-Petersson, Inês Araújo and Vitor Fernandes, from UAlg, and Martha Clokie and Nathan Brown, from UoL. The project, in the biomedical research area, titled “Evaluation of eradication of Shigellosis by the Treatment with Bacteriophages in Mus Musculus“, results from a grant awarded to Martha Clokie and Nathan Brown, by the Bill and Melinda Gates Foundation and will be developed, in part, at the University of Algarve, by the CBMR members mentioned above.  The main goal of this project is to evaluate the therapeutic potential of bacteriophages against Shigellosis, a burden that affects thousands of children in developing countries.

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Seven Algarve entities make “Algarve Coração Seguro” an official consortium

Com o objetivo de garantir mais saúde, segurança e bem-estar à população do Algarve e a todos os que visitam a região, no dia 24 de maio, pelas 15h00, foi assinado um protocolo de colaboração, no Hotel Alísios, em Albufeira, intitulado “Algarve Coração Seguro”, que conta com a parceria de sete entidades algarvias, incluindo a Universidade do Algarve.

A iniciativa foi apadrinhada pelo secretário de estado da Saúde, Manuel Delgado.

Além do Centro Académico de Investigação e Formação Biomédica do Algarve (ABC), integram este consórcio a Administração Regional de Saúde (ARS) Algarve, a Comunidade Intermunicipal do Algarve (AMAL), a Região de Turismo do Algarve (RTA), a Associação dos Hotéis e Empreendimentos Turísticos do Algarve (AHETA), a Associação Empresarial da região do Algarve (NERA), e a Associação dos Industriais Hoteleiros e Similares do Algarve (AIHSA).

O ABC vai promover a realização de ações de formação em Suporte Básico de Vida (SBV) e Desfibrilhação Automática Externa (DAE) destinadas a operadores turísticos, hoteleiros, espaços comerciais e públicos, com vista a dotar e reforçar a capacidade de resposta dos profissionais da área do turismo e das diversas unidades hoteleiras da região para a prestação de primeiros socorros em situações de emergência. Desta forma, pretende-se que o Algarve seja uma região completamente segura, com uma maior rede de cuidados de suporte básico de vida e desfibrilhação automática externa, o que permitirá diminuir a mortalidade e as complicações em caso de paragem cardíaca.

Recorde-se que o Algarve Biomedical Center é um consórcio entre a Universidade do Algarve e o Centro Hospitalar do Algarve, que pretende reunir investigadores, alunos, profissionais de saúde e representantes de entidades ligadas ao ensino, formação, investigação científica e desenvolvimento regional. Tem como objetivo a melhoria dos cuidados de saúde da região do Algarve, sendo os cuidados pré-hospitalares um dos seus focos de ação, nomeadamente através do pelo Laboratório de Investigação e Formação em Emergência (LIFE) da Universidade do Algarve.

O ABC considera fundamental a união de esforços das várias entidades da área da saúde, e, por isso, lançou, em parceria com a ARS Algarve, o projeto Algarve Coração Seguro. Este projeto contará ainda com a participação ativa da Federação de Bombeiros do Algarve.

 

 

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Researchers from CBMR develop a new approach to cancer treatment

Patrícia Silva, PhD student at UAlg, in the Cell Cycle and Cancer Biology Group, published, together with Claudia Florindo and Álvaro Tavares, a paper in Cancer Letters describing a new and possibly effective approach to therapeutic intervention in cancer. This work, coordinated by Hassam Bousbaa of CESPU, had the collaboration of a research group at IPATIMUP/i3S, led by Helena Vasconcelos.

In this study the researchers showed that by silencing the Spindly protein one can potentiate the efficacy of paclitaxel, one of the drugs most used in the treatment of cancer, in the death of cancer cells in culture. If combined, Spindly inhibition and the use of reduced doses of paclitaxel may be a positive advance in the treatment of cancer.

More information: http://sicnoticias.sapo.pt/pais/2017-05-23-Investigadores-do-Porto-descobrem-como-levar-as-celulas-cancerigenas-ao-suicidio

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Integrated Master in Medicine shows up in Paris

The department of Biomedical Sciences and Medicine (UAlg) will present, from 24th to 28th June, an unprecedented presentation at the IFOS World Congress, in Paris. On the behalf of this participation and with the objective of show the work developed at the academy, the students will present three oral communications and two posters.

The event, one of the most representative worldwide in the area of Medicine, will also feature a keynote speaker from University of Algarve.