In June, a protocol of collaboration was established between the CBMR (University of Algarve) and the University of Leicester (UoL, United Kingdom). The members of this collaboration are the researchers Karl Magnus-Petersson, Inês Araújo and Vitor Fernandes, from UAlg, and Martha Clokie and Nathan Brown, from UoL. The project, in the biomedical research area, titled “Evaluation of eradication of Shigellosis by the Treatment with Bacteriophages in Mus Musculus“, results from a grant awarded to Martha Clokie and Nathan Brown, by the Bill and Melinda Gates Foundation and will be developed, in part, at the University of Algarve, by the CBMR members mentioned above. The main goal of this project is to evaluate the therapeutic potential of bacteriophages against Shigellosis, a burden that affects thousands of children in developing countries.
Com o objetivo de garantir mais saúde, segurança e bem-estar à população do Algarve e a todos os que visitam a região, no dia 24 de maio, pelas 15h00, foi assinado um protocolo de colaboração, no Hotel Alísios, em Albufeira, intitulado “Algarve Coração Seguro”, que conta com a parceria de sete entidades algarvias, incluindo a Universidade do Algarve.
A iniciativa foi apadrinhada pelo secretário de estado da Saúde, Manuel Delgado.
Além do Centro Académico de Investigação e Formação Biomédica do Algarve (ABC), integram este consórcio a Administração Regional de Saúde (ARS) Algarve, a Comunidade Intermunicipal do Algarve (AMAL), a Região de Turismo do Algarve (RTA), a Associação dos Hotéis e Empreendimentos Turísticos do Algarve (AHETA), a Associação Empresarial da região do Algarve (NERA), e a Associação dos Industriais Hoteleiros e Similares do Algarve (AIHSA).
O ABC vai promover a realização de ações de formação em Suporte Básico de Vida (SBV) e Desfibrilhação Automática Externa (DAE) destinadas a operadores turísticos, hoteleiros, espaços comerciais e públicos, com vista a dotar e reforçar a capacidade de resposta dos profissionais da área do turismo e das diversas unidades hoteleiras da região para a prestação de primeiros socorros em situações de emergência. Desta forma, pretende-se que o Algarve seja uma região completamente segura, com uma maior rede de cuidados de suporte básico de vida e desfibrilhação automática externa, o que permitirá diminuir a mortalidade e as complicações em caso de paragem cardíaca.
Recorde-se que o Algarve Biomedical Center é um consórcio entre a Universidade do Algarve e o Centro Hospitalar do Algarve, que pretende reunir investigadores, alunos, profissionais de saúde e representantes de entidades ligadas ao ensino, formação, investigação científica e desenvolvimento regional. Tem como objetivo a melhoria dos cuidados de saúde da região do Algarve, sendo os cuidados pré-hospitalares um dos seus focos de ação, nomeadamente através do pelo Laboratório de Investigação e Formação em Emergência (LIFE) da Universidade do Algarve.
O ABC considera fundamental a união de esforços das várias entidades da área da saúde, e, por isso, lançou, em parceria com a ARS Algarve, o projeto Algarve Coração Seguro. Este projeto contará ainda com a participação ativa da Federação de Bombeiros do Algarve.
Patrícia Silva, PhD student at UAlg, in the Cell Cycle and Cancer Biology Group, published, together with Claudia Florindo and Álvaro Tavares, a paper in Cancer Letters describing a new and possibly effective approach to therapeutic intervention in cancer. This work, coordinated by Hassam Bousbaa of CESPU, had the collaboration of a research group at IPATIMUP/i3S, led by Helena Vasconcelos.
In this study the researchers showed that by silencing the Spindly protein one can potentiate the efficacy of paclitaxel, one of the drugs most used in the treatment of cancer, in the death of cancer cells in culture. If combined, Spindly inhibition and the use of reduced doses of paclitaxel may be a positive advance in the treatment of cancer.
The department of Biomedical Sciences and Medicine (UAlg) will present, from 24th to 28th June, an unprecedented presentation at the IFOS World Congress, in Paris. On the behalf of this participation and with the objective of show the work developed at the academy, the students will present three oral communications and two posters.
The event, one of the most representative worldwide in the area of Medicine, will also feature a keynote speaker from University of Algarve.
Wolfgang Link, CBMR researcher, published the article “Immunology: Mind the immuno-connection gap” in Nature Chemical Biology. As part of the Springer Nature Content the article explore the way how, in the last years, biologic drugs modulate the immune system and have revolutionized the therapeutic landscape for several selected cancer types. This new study reports an image–based assay system to monitor cell–cell interactions, identifying small-molecule compounds with immunomodulatory capacity.
Read the article here.
Patrícia Madureira, CBMR researcher, will participate on the Glioma Invasion Forum 2017, that will be held on Slovenia, from 23 to 25th april.
The researcher will present the communication “The role of the plasminogen system in glioma invasion”, on the Session III – Protease and other signaling pathways.
More information: http://conferences.nib.si/gif2017/
Inês Araújo, Vanessa Machado, Ana Sofia Lourenço and Cláudia Florindo, CBMR researchers, published recently the article: “Calpastatin overexpression preserves cognitive function following seizures, while maintaining post-injury neurogenesis”.
This article is an open access publication accessible to readers anywhere in the world.
Know more about this research here.
A group of CBMR researchers, led by Wolfgang Link, published in Nature Communications the results of an unprecedented research in the field of cancer. Recognizing the fact that intrinsic and acquired resistance to chemotherapy is a fundamental reason for treatment failure for many cancer patients, the researchers aimed to understand how cancer cells are, or become resistant, to the conventional therapies. At this article the researchers report that tribbles homolog 2 (TRIB 2) confers resistance to various chemotherapeutics by affecting critical cellular networks (PI3K and AKT) required by chemotherapy to kill cancer cells. TRIB2 does this by binding to a key protein in the cell, allowing increased cell division and repressing cell death.
Researchers also discovered that TRIB2 expression is very high in many patients and this results in an extremely poor clinical outcome. So, the study reveals a novel regulatory mechanism underlying chemotherapy drug resistance.
The discovery, which is completely unprecedented, allows to contribute to the development of new therapies for patients with high levels of this protein, helping to achieve more effective treatments and, consequently, increasing the survival rate.
The study, carried out by Richard Hill, Patrícia Madureira, Bibiana Ferreira, Inês Baptista, Laura Colaço, Susana Machado and Wolfgang Link, also aroused the interest of Bayer, that, in 2012, gave financial support to the project.
This publication promises to revolutionize the effectiveness of chemotherapy treatments and opens doors to the emergence of personalized medicine.
Read the article here.
The Department of Biomedical Sciences and Medicine (DCBM) inaugurated this month the exhibition “ArtDEVO_the hidden beauty of the embryo”, an exhibition of scientific photography. The exhibition, which was previously at Museum of Natural History, in Lisbon, brings together works of several national researchers belonging to reference centers such as the Instituto Gulbenkian de Ciência, Champalimaud Foundation and Instituto de Medicina Molecular de Lisboa. Also on exhibition is the work of University of Algarve researchers – Tomás Azevedo (from CBMR – Centre for Biomedical Research) and Marco Campinho (from CCMAR – Centre of Marine Sciences).
The exhibition is open to the general public until 15th April and can be visited every day, from 9 am to 5:30 pm, at Building 2, Campus de Gambelas.
About the exhibition:
Exhibition organized by the Portuguese Society for Developmental Biology (www.spbd.pt) to mark its 10th year anniversary.
Developmental Biology is the science that studies all the processes involved in the development of a being from fertilization until birth. Since a cell – the egg – which divides to give rise to many millions of cells that have to organize themselves, cooperate, compete, communicate and sometimes die to form a healthy multicellular organism.
Developmental Biology studies all this at the cellular and molecular level! It is from this research that arise countless gorgeous images that we now want to share with you!
The photos on display result from the work of our Developmental Biologists and were selected by an outstanding panel composed of scientists, artists, designers and communicators:
Alexandre Farto_VHILS, António Coutinho, Catarina Ramos, Gil Costa, Luís Barra, Manuel Costa Cabral, Maria Mota, Marta Vitorino, Mónica Bettencourt Dias e Sara Sá.
More information: http://www.museus.ulisboa.pt/pt-pt/art-devo
Cláudia Florindo, CBMR researcher, will be one of the teachers of the “9th Course on Optical Microscopy Imaging for Biosciences”. The miscroscopy couse will be held from 27th to 31th march, at i3S – Instituto de Investigação e Inovação (Porto).
The 9th Course on Optical Microscopy Imaging for Biosciences is a comprehensive and intensive course focus on the basis of modern light microscopy and designed to post-graduate students, early career researchers and all people interested in to acquire skills in optical microscopy.
The course explores the principles of optical microscopy including fundamentals of light microscopy and optical contrast techniques; principles of widefield and confocal fluorescence microscopy; live cell imaging and advanced microscopy applications; “super-resolution” microscopy; and digital image analysis.
This course includes lectures taught by specialists in microscopy and digital imaging and practical sessions supported by the major microscopy companies.