Universidade do Algarve | 12h00 | Auditorium 1.8.1
Title: “Gone rogue: IL-7 and IL-7R in leukemia”
Abstract: Interleukin-7 (IL-7) and its receptor (IL-7R) are essential for the normal development and homeostasis of lymphoid cells. In addition, IL-7 activates a number of anti-tumoral immune cell-dependent mechanisms. However, IL-7 and IL-7R can also go rogue and become detrimental to the organism by stimulating the proliferation and survival of malignant lymphoid cells and contributing to the development of leukemia. I will talk about some of the mechanisms by which IL-7/IL-7R signaling promotes leukemia growth in vitro and in vivo.
Short Bio: Group Leader at iMM Lisboa since 2006. Invited Associate Professor at Faculdade de Medicina da Universidade de Lisboa. Post-doctoral researcher at iMM Lisboa, Institut Pasteur, France, and Utrecht University, The Netherlands. PhD (2003) in Biomedical Sciences at Harvard Medical School, USA, and Universidade do Porto.