G. For details on the Rx drug Provigil, please click here . Some people have had success in adjusting their brain chemistry with over the counter, non-Rx, amino acid supplements, such as Phenylalanine. Serotonin has several important receptors called 5-HT1A, 5-HT2, 5-HT3. Additionally, one should keep in mind there are many other specific causes of depression, such as impaired Phenylalanine metabolism which inhibits endorphin receptors. Alternatives: As with insomnia (see benzodiazepine hypnotics, above), it's important to identify the cause of excessive daytime sleepiness. For a paper on the use of Provigil (Modafinil) for Idiopathic Hypersomnia (a term that sleep researchers use for chronic fatigue), please click here . Braverman and Pfeiffer, in "The Healing Nutrients Within", suggest that L-phenylalanine works best in bipolar disorders (with manic and depressive states) in doses of 500 mg twice daily (not more than 2-3 grams daily), along with 100 mg vitamin B6 provigil for hypothyroidism twice daily. When such underlying conditions are treated appropriately, there's rarely, if ever, any need for the use of stimulants. The resulting "hangover effect" can manifest itself as depression. Subsequently, the ball bounces into the space between the pitcher and catcher and then bounces around a bit. It is not exactly sure what happens here, yet we know this has an affect on the amount of communication between the pitcher and catcher using that type of ball (neurotransmitter). Phenylalanine is the precursor of the amino acid tyrosine and is therefore used to make noradrenaline and other catecholamines (type of neurotransmitter) such as epinephrine, dopamine, and tyramine. If you are fatigued, you may benefit from a noradrenaline medication; and if you are depressed (sad, disinterested), a serotonin medication. ) With the noradrenaline (NA) neurotransmitter, for example, two of the receptors are called "alpha-1" and "alpha-2" (catcher with #1 on his shirt, and catcher with #2 on his shirt, each with their own special phone line). It is essential for many bodily functions and is one of the few amino acids that can cross the blood-brain barrier (from blood to brain) and thus directly affect brain chemistry. Sleepiness? Provigil (Modafinil = Modiodal) is an NA-Agonists that stimulates the NA alpha-1 receptor. They also suggest that D- and DL-phenylalanine works better for affective (lack of positive attitude or emotional enthusiasm for life) depression. Melatonin, a dietary supplement that helps control sleep and wake cycles, may also be worth trying. It's important that you do not discontinue them on your own. If the catcher glove had been clogged, an Agonists can help unclog it by stimulating it. If you suspect that your depression symptoms are linked to a prescription drug you're taking, talk to your doctor or health care provider right away. In doctor lingo, it is a CNS (central nervous can i drink on provigil system) alpha-1 adrenergic Agonist. For an example of a study that found that Provigil is not harmful (e. Is that like fatigue? Agonists are often selective, in that they accelerate the activity of a specific kind of receptor for one neurotransmitter (e. When this happens, the ball hits a wall behind the pitcher and it bounces back to the catcher. One of the omeprazole provigil drugs you're on could be the cause. NA-Agonists have been used in Europe during the 1990's, and are just beginning to become popular in the USA. Phenylalanine is it ok to snort provigil metabolism requires pyridoxine (P5P or B6), niacin (B3), vitamin C, copper, and iron. Yes. These make it harder for the catcher to catch the ball by clogging it up a little. For example, levodopa, the can provigil raise blood pressure most commonly prescribed Parkinson's medication, is converted into dopamine on entering the brain; it's typically combined with carbidopa, which helps prevent it from breaking down before it can reach the brain and take effect, in brand-name products such as Atamet, Sinemet and Stalevo. Catcher #5 can provigil raise blood pressure that catches Pears). In fact, if they get into bed during the day, they may feel like they need to get out of bed, since it is daytime, and they can provigil raise blood pressure cannot sleep at that time. This naturally occuring amino acid is readily available in most food products, particularly meats and milk products, with lower levels found in oats and wheat germ. Older people are more likely to experience these residual effects because their livers often lack a key enzyme needed to metabolize the drugs. Alternatives: Give yourself every chance to sleep well naturally: Go to bed and wake up at the same times every day, avoid meals within two hours of bedtime, allow 30 minutes before bedtime for a relaxing pre-sleep ritual, and so forth. It is FDA approved and is used to effectively reduce sleepiness for people with narcolepsy. These people are not fatigued, they are "depressed". Are you feeling depressed? Serotonin is often associated with the more classical forms of depression, and noradrenaline is often associated with fatigue. These folks may not be interested can provigil raise blood pressure in sleeping. All of these alpha-1 items result in more energy for the person. Anything that causes a disregulation of the serotonin neurotransmitter, or clogs a seratonin receptor provigil and hormonal birth control such as 5-HT2 , can cause depression. A specific catcher thinks he just caught a piece of fruit, and he subsequently gets on the phone). Examples of drugs that do this with serotonin are called Serzone and Desyrel. 1. G. Beta-blockers There is another class of drug called an Agonists. To learn about the pitfuls of long term use, please click here . For a study can provigil raise blood pressure that found that Provigil does not hurt one's hormones, please see REFERENCE #11 . Drugs with sedating effects, for example, are among the most common causes of excessive daytime sleepiness. If not fully metabolized can provigil raise blood pressure in the liver, they can build up in the body to toxic levels. Other medications you're taking — whether prescription or over the counter — could be responsible. To learn more about studies involving Provigil, search "Modafinil" at Medline after 1990. Why they're prescribed: Anticonvulsant drugs, which have long been used to treat seizures, are increasingly being used to treat other medical conditions, including neuropathic pain, bipolar disorder, mood disorders and mania. There is a class of drug called a reuptake inhibitor, which clogs the pitcher's glove (or makes it smaller) and makes it hard for him to catch the ball when the catcher throws it back to him. (These include alpha- and beta-blockers, anti-diarrheal agents, antihistamines, antipsychotics, antispasmodics, cough suppressants, epilepsy drugs, skeletal muscle relaxants, Parkinson's drugs and some antidepressant medications. G. E. Examples: carbamazepine (Tegretol), gabapentin (Neurontin), lamotrigine (Lamictal), pregabalin (Lyrica) and topiramate (Topamax). Phenylalanine is better absorbed than tyrosine and produces fewer headaches, so may be more useful in depression than taking L-tyrosine directly. By a pesky heavy metal molecule), one would feel fatigued. Phenylalanine has been used for treatment of depression in the D-, L-, or DL- forms, probably because it increases tyrosine, the excitatory neurotransmitter. Nondrug causes of excessive daytime sleepiness include sleep deprivation, obstructive sleep apnea (when the throat muscles intermittently relax and block the airway during sleep) and depression. How they can cause depression: Benzodiazepines are central nervous system depressants. NA-Agonists are sometimes referred to as "Noradrenergic Agonists", and Agonists for serotonin called "Serotonin Agonists". For a study that looked at the noradrenic properties of Provigil, please see REFERENCE #12 . These stimulate specific receptors to make them think they just received a neurotransmitter molecule (i. There is another class of drug called an Antagonists. Noradrenaline is an important neurotransmitter is apparently important for memory, alertness, and learning. Not habit forming) over a long period of time and helped people with narcolepsy, please see REFERENCE #10 . Alpha-1 also stimulates the consumption of oxygen (O2) by the cells and stimulates the conversion of fatty acid in blood to energy. Classical depression is associated with feelings of melancholy, disinterest in life, boredom, a lack of enjoyment in life, and self doubt. To see examples of studies on noradrenaline receptors, please click here . The Alfa-1-receptors stimulate the conversion of liver molecules to sugar molecules (glucogenolysis), resulting in more glucose in the blood. If the alpha-1 receptors are clogged (e. Read below for the major classes of drugs that can cause depression. The following things can clog NA alpha-1 receptors: antagonist drugs, lead, mercury, cadmium, sulfur-toxins, over 70,000 manmade chemicals, and several natural toxins.
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